Analgesic effects of oral THC and similar effects to smoked cannabis

In healthy regular consumers of cannabis THC oral (dronabinol) and cannabis (marijuana) smoking had similar effects on sensitivity and tolerance to pain. This is the result of a study by the New York State Psychiatric Institute and Department of Psychiatry, Faculty of Medicine and Surgery at the University of Columbia in New York, USA, participated in the same 15 men and 15 healthy women daily smokers of cannabis and painkillers, subjective and physiological effects of cannabis (with 0’0, 1.98, and 3.56% compared to THC) and THC oral (0, 10 and 20 mg).

The response to pain by cold pressor test (CPT) was evaluated: participants immerse his left hand in cold water (4 ° C) and the time it takes to say they notice pain (pain sensitivity) and remove registers the hand water (pain tolerance).

Compared with placebo, cannabis and oral THC decreased sensitivity to pain (3.56%; 20 mg), increased pain tolerance (1.98%; 20 mg) and subjective scores decreased pain intensity (1.98, 3.56%; 20 mg). The magnitude of the maximum change in sensitivity and pain tolerance did not differ between cannabis and THC oral, although the analgesia caused the oral THC was longer.

The authors conclude that “these data indicate that, under controlled conditions, marijuana and dronabinol reduce pain, and that dronabinol produces a longer lasting decrease in sensitivity to lower pain scores subjective effects related to abuse that marijuana “.

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